Convergence between CD98 and integrin-mediated T-lymphocyte co-stimulation

Phosphoinositide 3-kinase and CD28-mediated T-cell co-stimulation.

Introduction Activation of resting T lymphocytes requires at least two signals: one provided by engagement of the T-cell antigen receptor (TCR)-CD3 complex by foreign antigen associated with self-major histocompatibility complex and the second by costimulatory molecule(s) present on antigen presenting cells (reviewed in [l]) . These signals trigger the GO-G1 transition of the cell cycle as well...

Functional Dichotomy between NKG2D and CD28-Mediated Co-Stimulation in Human CD8+ T Cells

Both CD28 and NKG2D can function as co-stimulatory receptors in human CD8+ T cells. However, their independent functional contributions in distinct CD8+ T cell subsets are not well understood. In this study, CD8+ T cells in human peripheral blood- and lung-derived lymphocytes were analyzed for CD28 and NKG2D expression and function. We found a higher level of CD28 expression in PBMC-derived naï...

Positive and negative regulation by SLP-76/ADAP and Pyk2 of chemokine-stimulated T-lymphocyte adhesion mediated by integrin α4β1 ABSTRACT Stimulation by chemokines of integrin α4β1–dependent T-lymphocyte adhesion

Stimulation by chemokines of integrin α4β1–dependent T-lymphocyte adhesion is a crucial step for lymphocyte trafficking. The adaptor Vav1 is required for chemokine-activated T-cell adhesion mediated by α4β1. Conceivably, proteins associating with Vav1 could potentially modulate this adhesion. Correlating with activation by the chemokine CXCL12 of T-lymphocyte attachment to α4β1 ligands, a trans...

Lymphocyte Activation — B- and T-Cell Activation, Germinal Center and Co-stimulation

Lymphocyte Activation — B- and T-Cell Activation, Germinal Center and Co-stimulation